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  • Denis Pepin

The Promise of Engineered Universal Blood: A Revolution on the Horizon

Updated: May 10

An image depicting a close-up view of red blood cells in a vibrant red and blue environment, resembling the inside of a blood vessel.
“A vivid journey through the bloodstream, showcasing the bustling life of red blood cells.” This image beautifully captures the essence of our circulatory system. (CyberNesco)

For decades, blood transfusions have relied on a complex system of matching blood types. This system, while effective, faces limitations. Blood shortages are a constant concern, and finding compatible blood can be time-consuming, especially in emergencies. However, recent scientific advancements offer a glimpse into a future with "engineered universal blood" – a solution that could revolutionize transfusions and save countless lives.


One promising approach lies in manipulating existing blood types. A recent study published in Nature Microbiology sheds light on this exciting development. Researchers identified the specific culprit behind blood type incompatibility: long sugar molecules decorating the surface of red blood cells. These sugars act like identification tags, triggering an immune response if they are not recognized by the recipient's body.

The researchers took an ingenious approach to overcome this hurdle. They turned to a surprising source for the solution – gut bacteria. Our gut houses a diverse community of bacteria, some of which produce enzymes capable of breaking down complex sugars found in mucus. As Dr. Martin Olsson, a professor of hematology and transfusion medicine at Lund University in Sweden, stated, "The mucus in our gut does [look like a red blood cell surface]. So, we simply borrowed the enzymes from the bacteria that normally metabolize mucus and then applied them to the red blood cells". This "cocktail" of gut bacteria enzymes effectively stripped away the problematic sugar chains, essentially cloaking type A and B blood cells in disguise. Disguised as type O, the universal donor type, these modified cells could potentially be transfused into anyone without triggering an immune reaction.


This approach holds immense potential. With any blood type potentially becoming universally compatible, blood shortages could become a thing of the past. However, the journey from promising research to widespread use requires further refinement. Safety remains paramount. Researchers need to ensure the modified blood cells function normally within the recipient's body and don't trigger unintended immune responses. Additionally, the efficiency and scalability of the enzyme treatment process need significant improvement. Currently, the process might be time-consuming and require large quantities of enzymes. Optimizing this process is crucial for making universal blood a practical solution in hospital settings.

Another avenue towards universal blood lies in the realm of cellular engineering, where scientists are exploring the possibility of growing red blood cells directly in the lab using stem cells. These lab-grown cells wouldn't have any blood-type antigens on their surface, making them universally compatible. Initial clinical trials involving small-scale transfusions with lab-grown red blood cells have shown promising results.


The potential impact of engineered universal blood is profound. It could revolutionize blood transfusions by:

  • Eliminating blood shortages: With any blood type potentially becoming universally compatible, the limitations of the current blood type matching system would be overcome.

  • Improving patient outcomes: Faster access to compatible blood during emergencies could lead to better patient outcomes and reduce complications.

  • Reducing healthcare costs: Streamlining blood donation and transfusion procedures could lead to significant cost savings for healthcare systems.

  • Enhancing quality of life: For patients with chronic blood conditions, lab-grown blood with a potentially longer lifespan could reduce the burden of frequent transfusions.


The road to engineered universal blood is paved with scientific exploration and technological advancements. However, the potential benefits are undeniable. As research continues, the day when blood type compatibility becomes a thing of the past may not be far off. This will usher in a new era of transfusions, one that is more efficient, readily available, and ultimately, life-saving.


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